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Article

A two-stage mixed-effects model approach for gene-set analyses in candidate gene studies.

Statistics in medicine - 20 May 2012

Tsonaka Roula, van der Helm-van Mil Annette H M, Houwing-Duistermaat Jeanine J

Abstract excerpt

In genetic association studies, a gene-set analysis can be more powerful than the separate analyses of multiple genetic variants and can offer unique insights into the genetic basis of many common human diseases. The goal of such an analysis is to study the joint effect of multiple single-nucleotide polymorphisms (SNPs) which belong to certain genes, and these genes are assumed to be involved in a common...

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PMID: 21997511
DOI: 10.1002/sim.4370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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