Article
An efficient multi-locus mixed-model approach for genome-wide association studies in structured populations.
Nature genetics - 17 Jun 2012
Segura Vincent, Vilhjálmsson Bjarni J, Platt Alexander, Korte Arthur, Seren Ümit, Long Quan, Nordborg Magnus
Abstract excerpt
Population structure causes genome-wide linkage disequilibrium between unlinked loci, leading to statistical confounding in genome-wide association studies. Mixed models have been shown to handle the confounding effects of a diffuse background of large numbers of loci of small effect well, but they do not always account for loci of larger effect. Here we propose a multi-locus mixed model as a general method for...
Topics
- Arabidopsis
- Bayes Theorem
- Chromosome Mapping
- Genetic Loci
- Genome, Human
- Genome, Plant
- Genome-Wide Association Study
- Genotype
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Molecular Dynamics Simulation
- Polymorphism, Single Nucleotide