Article
Improving power and accuracy of genome-wide association studies via a multi-locus mixed linear model methodology.
Scientific reports - 20 Jan 2016
Wang Shi-Bo, Feng Jian-Ying, Ren Wen-Long, Huang Bo, Zhou Ling, Wen Yang-Jun, Zhang Jin, Dunwell Jim M, Xu Shizhong, Zhang Yuan-Ming
Abstract excerpt
Genome-wide association studies (GWAS) have been widely used in genetic dissection of complex traits. However, common methods are all based on a fixed-SNP-effect mixed linear model (MLM) and single marker analysis, such as efficient mixed model analysis (EMMA). These methods require Bonferroni correction for multiple tests, which often is too conservative when the number of markers is extremely large. To address...
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