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Article

X chromosome-wide association studies for quantitative trait loci based on the mixture of general pedigrees and additional unrelated individuals.

Briefings in bioinformatics - 1 Sept 2026

Wei Yi-Fang, Zhang Rui-Xiang, Zhang Shun, Zhong Qi, Li Yuan-Sheng, Mai Jia-Hao, Wu Xian-Bo, Zhou Ji-Yuan

Abstract excerpt

Genome-wide association studies have successfully identified many genetic variants associated with complex traits. However, most existing methods target autosomes rather than X chromosome, and several existing X chromosome-wide association studies (XWAS) at quantitative trait loci (QTL) largely focus on unrelated individuals, with limited attention to general pedigrees or mixture of general pedigrees and...

Read the complete abstract on PubMed

Topics

Quantitative Trait Loci
Pedigree
Genome-Wide Association Study
Humans
Chromosomes, Human, X
Polymorphism, Single Nucleotide

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Identifiers

PMID: 42691152
DOI: 10.1093/bib/bbag467
PMCID: PMC13540756

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