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Article

Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2012

Chen Yaomin, Huang Xiumei, Zhang Yun-wu, Rockenstein Edward, Bu Guojun, Golde Todd E, Masliah Eliezer, Xu Huaxi

Abstract excerpt

β-Amyloid protein (Aβ), the major component of neuritic plaques in Alzheimer's disease (AD), is derived from proteolytic cleavages of the amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) and the γ-secretase complex. BACE1 is the rate-limiting enzyme for Aβ production, and an increase in BACE1 level/activity contributes to the pathogenesis of sporadic AD. In addition to cleaving APP for Aβ...

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Source

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Identifiers

PMID: 22895721
DOI: 10.1523/JNEUROSCI.0757-12.2012
PMCID: PMC3446780

Genes

BACE1
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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