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Article

Activation of protein kinase C modulates BACE1-mediated beta-secretase activity.

Neurobiology of aging - 1 Mar 2008

Wang Lizhen, Shim Hoon, Xie Chengsong, Cai Huaibin

Abstract excerpt

beta-Site APP cleavage enzyme 1 (BACE1) is the beta-secretase responsible for generating amyloid-beta (A beta) peptides in Alzheimer's disease (AD). Previous studies suggest that activation of protein kinase C (PKC) modulates the beta-secretase-mediated cleavage of APP and reduces the production of A beta. The mechanism of PKC-mediated modulation of beta-secretase activity, however, remains elusive. We report...

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Source

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Identifiers

PMID: 17157415
DOI: 10.1016/j.neurobiolaging.2006.11.001
PMCID: PMC2278113

Genes

BACE1
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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