Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer's disease.

Trends in pharmacological sciences - 1 Jan 2006

Beglopoulos Vassilios, Shen Jie

Abstract excerpt

Alzheimer's disease (AD) is the most common neurodegenerative disorder and is characterized by memory loss and other cognitive disabilities. Mutations in the presenilin genes are the major cause of familial AD. Analysis of conditional knockout mice has shown that inactivation of presenilins results in progressive memory impairment and age-dependent neurodegeneration, suggesting that reduced presenilin activity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3',5'-Cyclic-AMP Phosphodiesterases
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP

Share to Cyclic Nucleotide Phosphodiesterases, Type 4

Share to Memory

Share to Presenilin-1

Share to Presenilin-2

Share to Response Elements

Source

Identifiers

PMID: 16337694
DOI: 10.1016/j.tips.2005.11.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer's disease.PMID 16337694Read ↗

CREB: A Multifaceted Target for Alzheimer’s DiseaseSemantic proximity Read ↗

The role of CREB signaling in Alzheimer’s disease and other cognitive disordersSemantic proximity Read ↗

Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid.Semantic proximity Read ↗

Crtc1 Activates a Transcriptional Program Deregulated at Early Alzheimer's Disease-Related StagesSemantic proximity Read ↗

Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer’s DiseaseSemantic proximity Read ↗

Transcriptional regulation of the presenilin-1 gene: implication in Alzheimer's disease.Semantic proximity Read ↗

CREB-regulated transcription coactivator 1-dependent transcription in Alzheimer's disease mice.Semantic proximity Read ↗

Presenilins in the Developing, Adult, and Aging Cerebral CortexSemantic proximity Read ↗

Presenilin mouse and zebrafish models for dementia: focus on neurogenesis.Semantic proximity Read ↗

Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice.Semantic proximity Read ↗

Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling.Semantic proximity Read ↗

Preventing Jacob-induced transcriptional inactivation of CREB protects synapses from β-amyloid in Alzheimer’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.