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Article

CREB-regulated transcription coactivator 1-dependent transcription in Alzheimer's disease mice.

Neuro-degenerative diseases - 1 Jan 2012

Saura Carlos A

Abstract excerpt

BACKGROUND/AIMS: Long-term memory requires fine-tuning regulation of gene expression in specific neural circuits of the brain. Transcriptional regulation of gene programs is a key mechanism for memory storage and its deregulation may contribute to synaptic and cognitive dysfunction in memory disorders. The molecular mechanisms underlying changes on activity-dependent gene expression in Alzheimer's disease (AD)...

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Source

Identifiers

PMID: 22236576
DOI: 10.1159/000333341

Genes

CRTC1
APP

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