Article
BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes.
Molecular and cellular neurosciences - 1 Nov 2003
Harrison Steve M, Harper Alex J, Hawkins Julie, Duddy Graham, Grau Evelyn, Pugh Pippa L, Winter Panida H, Shilliam Claire S, Hughes Zoë A, Dawson Lee A, Gonzalez M Isabel, Upton Neil, Pangalos Menelas N, Dingwall Colin
Abstract excerpt
BACE1 is a key enzyme in the generation of Abeta, the major component of senile plaques in the brains of Alzheimer's disease patients. We have generated transgenic mice expressing human BACE1 with the Cam Kinase II promoter driving neuronal-specific expression. The transgene contains the full-length coding sequence of human BACE1 preceding an internal ribosome entry site element followed by a LacZ reporter gene....
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