Article
A single Cys706 to Phe substitution in the retinoblastoma protein causes the loss of binding to SV40 T antigen.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 1990
Bignon Y J, Shew J Y, Rappolee D, Naylor S L, Lee E Y, Schnier J, Lee W H
Abstract excerpt
Most naturally occurring mutants of the retinoblastoma (RB) protein contain large deletions or truncations. The small cell lung carcinoma cell line H209 contains a normal-sized but unphosphorylated RB protein (Hensel et al., Cancer Res., 50: 3067-3072, 1990), which fails to form a complex with SV...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Polyomavirus Transforming
- Base Sequence
- Humans
- Molecular Sequence Data
- Mutation
- Protein Binding
- Retinoblastoma Protein
- Structure-Activity Relationship
- Tumor Cells, Cultured