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Article

A single Cys706 to Phe substitution in the retinoblastoma protein causes the loss of binding to SV40 T antigen.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 1990

Bignon Y J, Shew J Y, Rappolee D, Naylor S L, Lee E Y, Schnier J, Lee W H

Abstract excerpt

Most naturally occurring mutants of the retinoblastoma (RB) protein contain large deletions or truncations. The small cell lung carcinoma cell line H209 contains a normal-sized but unphosphorylated RB protein (Hensel et al., Cancer Res., 50: 3067-3072, 1990), which fails to form a complex with SV40 T antigen, suggesting that the RB gene of H209 may contain a subtle mutation. To define this mutation, the RB...

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PMID: 2288878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A single Cys706 to Phe substitution in the retinoblastoma protein causes the loss of binding to SV40 T antigen.PMID 2288878Read ↗

A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.Semantic proximity Read ↗

Functional analysis at the Cys706 residue of the retinoblastoma protein.Semantic proximity Read ↗

Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.Semantic proximity Read ↗

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.Semantic proximity Read ↗

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.Semantic proximity Read ↗

Converting the JCV T antigen Rb binding domain to that of SV40 does not alter JCV's limited transforming activity but does eliminate viral viability.Semantic proximity Read ↗

Retinoblastoma protein binding properties are dependent on 4 cysteine residues in the protein binding pocket.Semantic proximity Read ↗

The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F.Semantic proximity Read ↗

Conserved Region 3 of Human Papillomavirus 16 E7 Contributes to Deregulation of the Retinoblastoma Tumor SuppressorSemantic proximity Read ↗

SV40 T-Antigen Amino Acid Changes that Disrupt Cul-7 or Bub-1 Binding Do Not Globally Distort the T-Common Region.Semantic proximity Read ↗

Destabilization of the Retinoblastoma Tumor Suppressor by Human Papillomavirus Type 16 E7 Is Not Sufficient To Overcome Cell Cycle Arrest in Human KeratinocytesSemantic proximity Read ↗

Functional implications of mutations within polyomavirus large T antigen Rb-binding domain: effects on pRb and p107 binding in vitro and immortalization activity in vivo.Semantic proximity Read ↗

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