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Conserved Region 3 of Human Papillomavirus 16 E7 Contributes to Deregulation of the Retinoblastoma Tumor Suppressor

27 Sept 2012

Abstract excerpt

The human papillomavirus (HPV) E7 oncoprotein binds cellular factors, preventing or retargeting their function and thereby making the infected cell conducive for viral replication. A key target of E7 is the product of the retinoblastoma susceptibility locus (pRb). This interaction results in the release of E2F transcription factors and drives the host cell into the S phase of the cell cycle. E7 binds pRb via a...

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PMID: 23015707
DOI: 10.1128/jvi.01637-12

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Related research

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Conserved Region 3 of Human Papillomavirus 16 E7 Contributes to Deregulation of the Retinoblastoma Tumor SuppressorPMID 23015707Read ↗

Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor.Semantic proximity Read ↗

Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins.Semantic proximity Read ↗

Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoproteinSemantic proximity Read ↗

The Canine Papillomavirus and Gamma HPV E7 Proteins Use an Alternative Domain to Bind and Destabilize the Retinoblastoma ProteinSemantic proximity Read ↗

Induction of pRb Degradation by the Human Papillomavirus Type 16 E7 Protein Is Essential To Efficiently Overcome p16 <sup>INK4a</sup> -Imposed G <sub>1</sub> Cell Cycle ArrestSemantic proximity Read ↗

Systematic Analysis of the Amino Acid Residues of Human Papillomavirus Type 16 E7 Conserved Region 3 Involved in Dimerization and TransformationSemantic proximity Read ↗

Interactions with Pocket Proteins Contribute to the Role of Human Papillomavirus Type 16 E7 in the Papillomavirus Life CycleSemantic proximity Read ↗

Human Papillomavirus Type 16 E7 Oncoprotein Associates with the Cullin 2 Ubiquitin Ligase Complex, Which Contributes to Degradation of the Retinoblastoma Tumor SuppressorSemantic proximity Read ↗

The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradationSemantic proximity Read ↗

Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein DegradationSemantic proximity Read ↗

Retinoblastoma protein binding properties are dependent on 4 cysteine residues in the protein binding pocket.Semantic proximity Read ↗

Mutagenesis of the pRB Pocket Reveals that Cell Cycle Arrest Functions Are Separable from Binding to Viral OncoproteinsSemantic proximity Read ↗

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