Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.

doi:10.1002/j.1460-2075.1990.tb08306.x

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Article

Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.

The EMBO journal - 1 Jun 1990

Huang S, Wang N P, Tseng B Y, Lee W H, Lee E H

Abstract excerpt

The retinoblastoma susceptibility gene (RB) encodes a phosphoprotein of 110 kd (pp110RB) that forms specific complexes with SV40 T antigen and the transforming proteins of several other DNA tumor viruses. Interaction with RB is thought to contribute to transformation by these viruses as demonstrated by genetic analyses. To help understand the function of these interactions, the regions of RB that are involved in...

Topics

Antigens, Polyomavirus Transforming
Base Sequence
Chimera
Exons
Globins
Humans
Molecular Sequence Data
Mosaic Viruses
Mutation
Oncogenes
Phosphoproteins
Protein Biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

Restriction Mapping

Retinoblastoma

Retinoblastoma Protein

Transcription, Genetic

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 2189724
DOI: 10.1002/j.1460-2075.1990.tb08306.x
PMCID: PMC551886

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2189724-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.PMID 2189724Read ↗

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.Semantic proximity Read ↗

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.Semantic proximity Read ↗

Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.Semantic proximity Read ↗

Human retinoblastoma susceptibility gene.Semantic proximity Read ↗

Purified JC Virus T and T′ Proteins Differentially Interact with the Retinoblastoma Family of Tumor Suppressor ProteinsSemantic proximity Read ↗

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Converting the JCV T antigen Rb binding domain to that of SV40 does not alter JCV's limited transforming activity but does eliminate viral viability.Semantic proximity Read ↗

A single Cys706 to Phe substitution in the retinoblastoma protein causes the loss of binding to SV40 T antigen.Semantic proximity Read ↗

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Interaction of retinoblastoma protein family members with large T-antigen of primate polyomavirusesSemantic proximity Read ↗

SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation.Semantic proximity Read ↗

A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product.Semantic proximity Read ↗

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