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Article

Retinoblastoma protein binding properties are dependent on 4 cysteine residues in the protein binding pocket.

The Journal of biological chemistry - 25 Jul 1992

Stirdivant S M, Ahern J D, Oliff A, Heimbrook D C

Abstract excerpt

The retinoblastoma gene product (pRB) participates in regulating mammalian cell replication. The mechanism responsible for pRB's growth regulatory activity is uncertain. However, pRB is known to bind viral transforming proteins including the papilloma virus E7 protein, cellular proteins, and DNA. pRB contains a critical domain termed the "binding pocket" which is required for binding activities. This binding...

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PMID: 1321820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Retinoblastoma protein binding properties are dependent on 4 cysteine residues in the protein binding pocket.PMID 1321820Read ↗

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Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoproteinSemantic proximity Read ↗

The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F.Semantic proximity Read ↗

Conserved Region 3 of Human Papillomavirus 16 E7 Contributes to Deregulation of the Retinoblastoma Tumor SuppressorSemantic proximity Read ↗

Mutagenesis of the pRB Pocket Reveals that Cell Cycle Arrest Functions Are Separable from Binding to Viral OncoproteinsSemantic proximity Read ↗

Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins.Semantic proximity Read ↗

Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein familySemantic proximity Read ↗

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