Retinoblastoma protein binding properties are dependent on 4 cysteine residues in the protein binding pocket.

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Article

Retinoblastoma protein binding properties are dependent on 4 cysteine residues in the protein binding pocket.

The Journal of biological chemistry - 25 Jul 1992

Stirdivant S M, Ahern J D, Oliff A, Heimbrook D C

Abstract excerpt

The retinoblastoma gene product (pRB) participates in regulating mammalian cell replication. The mechanism responsible for pRB's growth regulatory activity is uncertain. However, pRB is known to bind viral transforming proteins including the papilloma virus E7 protein, cellular proteins, and DNA....

Topics

Antibodies
Cysteine
DNA
Enzyme-Linked Immunosorbent Assay
Humans
Mutagenesis, Site-Directed
Mutation
Oncogene Proteins, Viral
Papillomaviridae
Papillomavirus E7 Proteins
Plasmids
Precipitin Tests
Retinoblastoma Protein

Source

Open in PubMed

Identifiers

PMID: 1321820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1321820-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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