Article
Functional analysis at the Cys706 residue of the retinoblastoma protein.
The Journal of biological chemistry - 25 Dec 1992
Kratzke R A, Otterson G A, Lin A Y, Shimizu E, Alexandrova N, Zajac-Kaye M, Horowitz J M, Kaye F J
Abstract excerpt
A missense mutation at cysteine 706, resulting in a retinoblastoma (RB) protein defective in phosphorylation and oncoprotein binding, has been isolated from a human tumor cell line. Since this residue is conserved in murine RB and in the related p107 protein, we studied the activity of in vitro mutants flanking this position. These experiments demonstrated that the thiol atom at codon 706 does not possess...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.