Article
Functional analysis at the Cys706 residue of the retinoblastoma protein.
The Journal of biological chemistry - 25 Dec 1992
Kratzke R A, Otterson G A, Lin A Y, Shimizu E, Alexandrova N, Zajac-Kaye M, Horowitz J M, Kaye F J
Abstract excerpt
A missense mutation at cysteine 706, resulting in a retinoblastoma (RB) protein defective in phosphorylation and oncoprotein binding, has been isolated from a human tumor cell line. Since this residue is conserved in murine RB and in the related p107 protein, we studied the activity of in vitro m...
Topics
- Amino Acid Sequence
- Animals
- Carcinoma, Small Cell
- Codon
- Cysteine
- Exons
- Glutathione Transferase
- HeLa Cells
- Humans
- Lung Neoplasms
- Mice
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Proto-Oncogene Proteins c-myc
- Recombinant Fusion Proteins
- Retinoblastoma Protein
- Sequence Homology, Amino Acid