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Destabilization of the Retinoblastoma Tumor Suppressor by Human Papillomavirus Type 16 E7 Is Not Sufficient To Overcome Cell Cycle Arrest in Human Keratinocytes

1 Aug 2001

Abstract excerpt

The E7 oncoprotein of human papillomavirus type 16 promotes cell proliferation in the presence of antiproliferative signals. Mutagenesis of E7 has revealed that this activity requires three regions, conserved regions 1 and 2 and a C-terminal zinc finger. Binding to the retinoblastoma tumor repressor (Rb) through an LxCxE motif in conserved region 2 is necessary, but not sufficient, for E7 to induce proliferation....

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PMID: 11435552
DOI: 10.1128/jvi.75.15.6737-6747.2001

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Related research

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Destabilization of the Retinoblastoma Tumor Suppressor by Human Papillomavirus Type 16 E7 Is Not Sufficient To Overcome Cell Cycle Arrest in Human KeratinocytesPMID 11435552Read ↗

Inactivation of both the Retinoblastoma Tumor Suppressor and p21 by the Human Papillomavirus Type 16 E7 Oncoprotein Is Necessary To Inhibit Cell Cycle Arrest in Human Epithelial CellsSemantic proximity Read ↗

Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytesSemantic proximity Read ↗

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Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoproteinSemantic proximity Read ↗

The binding of histone deacetylases and the integrity of zinc finger-like motifs of the E7 protein are essential for the life cycle of human papillomavirus type 31.Semantic proximity Read ↗

Examination of the pRb-Dependent and pRb-Independent Functions of E7 In VivoSemantic proximity Read ↗

Induction of pRb Degradation by the Human Papillomavirus Type 16 E7 Protein Is Essential To Efficiently Overcome p16 <sup>INK4a</sup> -Imposed G <sub>1</sub> Cell Cycle ArrestSemantic proximity Read ↗

Human Papillomavirus Type 16 E7 Maintains Elevated Levels of the cdc25A Tyrosine Phosphatase during Deregulation of Cell Cycle ArrestSemantic proximity Read ↗

The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradationSemantic proximity Read ↗

Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins.Semantic proximity Read ↗

Inactivation of the RB1 and PTPN14 tumor suppressors cooperatively enables the carcinogenic activity of the human papillomavirus E7 oncoproteinSemantic proximity Read ↗

Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.Semantic proximity Read ↗

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