Article
Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.
Molecular and cellular biology - 1 Jul 1990
Kaelin W G, Ewen M E, Livingston D M
Abstract excerpt
It has previously been demonstrated that the simian virus 40 large T antigen and adenovirus E1A proteins can form complexes with the retinoblastoma susceptibility gene product (RB). We studied the ability of these proteins to bind to mutant RB proteins in vitro. A region of RB spanning residues 3...
Topics
- Adenovirus Early Proteins
- Adenoviruses, Human
- Animals
- Antigens, Polyomavirus Transforming
- Cell Line
- Chromosome Deletion
- DNA-Binding Proteins
- Genes, Viral
- Humans
- Mutation
- Oncogene Proteins, Viral
- Phosphoproteins
- Plasmids
- Polymerase Chain Reaction
- Protein Biosynthesis
- Retinoblastoma Protein
- Simian virus 40
- Transcription, Genetic