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Article

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.

Molecular and cellular biology - 1 Jul 1990

Kaelin W G, Ewen M E, Livingston D M

Abstract excerpt

It has previously been demonstrated that the simian virus 40 large T antigen and adenovirus E1A proteins can form complexes with the retinoblastoma susceptibility gene product (RB). We studied the ability of these proteins to bind to mutant RB proteins in vitro. A region of RB spanning residues 379 to 792 was found to be both necessary and sufficient for binding to T or E1A. Furthermore, this region of RB...

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Identifiers

PMID: 2162480
DOI: 10.1128/mcb.10.7.3761-3769.1990
PMCID: PMC360829

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.PMID 2162480Read ↗

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