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Article

Power of single- vs. multi-marker tests of association.

Genetic epidemiology - 1 Jul 2012

Wang Xuefeng, Morris Nathan J, Schaid Daniel J, Elston Robert C

Abstract excerpt

Current genome-wide association studies still heavily rely on a single-marker strategy, in which each single nucleotide polymorphism (SNP) is tested individually for association with a phenotype. Although methods and software packages that consider multimarker models have become available, they have been slow to become widely adopted and their efficacy in real data analysis is often questioned. Based on...

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PMID: 22648939
DOI: 10.1002/gepi.21642
PMCID: PMC3708310

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