Article
Genomic screening and replication using the same data set in family-based association testing.
Nature genetics - 1 Jul 2005
Van Steen Kristel, McQueen Matthew B, Herbert Alan, Raby Benjamin, Lyon Helen, Demeo Dawn L, Murphy Amy, Su Jessica, Datta Soma, Rosenow Carsten, Christman Michael, Silverman Edwin K, Laird Nan M, Weiss Scott T, Lange Christoph
Abstract excerpt
The Human Genome Project and its spin-offs are making it increasingly feasible to determine the genetic basis of complex traits using genome-wide association studies. The statistical challenge of analyzing such studies stems from the severe multiple-comparison problem resulting from the analysis of thousands of SNPs. Our methodology for genome-wide family-based association studies, using single SNPs or...
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