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Article

Crohn disease ATG16L1 polymorphism increases susceptibility to infection with Helicobacter pylori in humans.

Autophagy - 1 Sept 2012

Raju Deepa, Hussey Séamus, Jones Nicola L

Abstract excerpt

Autophagy plays key roles both in host defense against bacterial infection and in tumor biology. Helicobacter pylori (H. pylori) infection causes chronic gastritis and is the single most important risk factor for the development of gastric cancer in humans. Its vacuolating cytotoxin (VacA) promotes gastric colonization and is associated with more severe disease. Acute exposure to VacA initially triggers host...

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Source

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Identifiers

PMID: 22885761
DOI: 10.4161/auto.21007
PMCID: PMC3442886

Genes

CTSD
SQSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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