Article
Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans.
Gastroenterology - 1 May 2012
Raju Deepa, Hussey Seamus, Ang Michelle, Terebiznik Mauricio R, Sibony Michal, Galindo-Mata Esther, Gupta Vijay, Blanke Steven R, Delgado Alberto, Romero-Gallo Judith, Ramjeet Mahendra Singh, Mascarenhas Heidi, Peek Richard M, Correa Pelayo, Streutker Cathy, Hold Georgina, Kunstmann Erdmutte, Yoshimori Tamotsu, Silverberg Mark S, Girardin Stephen E, Philpott Dana J, El Omar Emad, Jones Nicola L
Abstract excerpt
BACKGROUND & AIMS: The Helicobacter pylori toxin vacuolating cytotoxin (VacA) promotes gastric colonization, and its presence (VacA(+)) is associated with more-severe disease. The exact mechanisms by which VacA contributes to infection are unclear. We previously found that limited exposure to VacA induces autophagy of gastric cells, which eliminates the toxin; we investigated whether autophagy serves as a defense...
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