Autophagy mediates ER stress and inflammation in Helicobacter pylori-related gastric cancer.

doi:10.1080/19490976.2021.2015238

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Autophagy mediates ER stress and inflammation in Helicobacter pylori-related gastric cancer.

Gut microbes - 1 Jan 2000

Mommersteeg M C, Simovic I, Yu B, van Nieuwenburg S A V, Bruno I M J, Doukas M, Kuipers E J, Spaander M C W, Peppelenbosch M P, Castaño-Rodríguez N, Fuhler G M

Abstract excerpt

Autophagy is a cellular degradation mechanism, which is triggered by the bacterium Helicobacter pylori. A single nucleotide polymorphism (SNP) in the autophagy gene ATG16L1 (rs2241880, G-allele) has been shown to dysregulate autophagy and increase intestinal endoplasmic reticulum (ER) stress. Here, we investigate the role of this SNP in H.pylori-mediated gastric carcinogenesis and its molecular pathways. ATG16L1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Australia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autophagy

Share to Autophagy-Related Proteins

Share to Endoplasmic Reticulum Stress

Share to Gastrointestinal Microbiome

Share to Helicobacter Infections

Share to Helicobacter pylori

Share to Netherlands

Source

Open in PubMed Open full text

Identifiers

PMID: 34965181
DOI: 10.1080/19490976.2021.2015238
PMCID: PMC8726742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autophagy mediates ER stress and inflammation in Helicobacter pylori-related gastric cancer.PMID 34965181Read ↗

Autophagy in Helicobacter pylori Infection and Related Gastric Cancer.Semantic proximity Read ↗

Helicobacter pylori and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease ProgressionSemantic proximity Read ↗

Crohn disease ATG16L1 polymorphism increases susceptibility to infection with Helicobacter pylori in humans.Semantic proximity Read ↗

Crohn's disease-associated ATG16L1 T300A genotype is associated with improved survival in gastric cancer.Semantic proximity Read ↗

Crohn's disease: NOD2, autophagy and ER stress converge.Semantic proximity Read ↗

Epigenetic regulation of autophagy in gastrointestinal cancersSemantic proximity Read ↗

Autophagy ATG16L1 rs2241880 impacts the colorectal cancer risk: A case-control study.Semantic proximity Read ↗

New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBDSemantic proximity Read ↗

Modulation of autophagy by Helicobacter pylori and its role in gastric carcinogenesisSemantic proximity Read ↗

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.Semantic proximity Read ↗

Determination of autophagy gene ATG16L1 polymorphism in human colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.