Article
Cytidine deaminase genetic variants influence RNA expression and cytarabine cytotoxicity in acute myeloid leukemia.
Pharmacogenomics - 1 Feb 2012
Abraham Ajay, Varatharajan Savitha, Abbas Salar, Zhang Wei, Shaji Ramachandran V, Ahmed Rayaz, Abraham Aby, George Biju, Srivastava Alok, Chandy Mammen, Mathews Vikram, Balasubramanian Poonkuzhali
Abstract excerpt
AIM: Cytidine deaminase (CDA) irreversibly deaminates cytarabine (Ara-C), a key component of acute myeloid leukemia (AML) induction and consolidation therapy. CDA overexpression results in Ara-C resistance, while decreased expression is associated with toxicity. We evaluated factors influencing variation in CDA mRNA expression in adult AML patients and normal controls, and how they contributed to Ara-C...
Topics
- 3' Untranslated Regions
- 5' Untranslated Regions
- Adolescent
- Adult
- Aged
- Base Sequence
- Case-Control Studies
- Cell Line, Tumor
- Cytarabine
- Cytidine Deaminase
- Drug Resistance, Neoplasm
- Female
- Gene Expression