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Article

Cytidine deaminase genetic variants influence RNA expression and cytarabine cytotoxicity in acute myeloid leukemia.

Pharmacogenomics - 1 Feb 2012

Abraham Ajay, Varatharajan Savitha, Abbas Salar, Zhang Wei, Shaji Ramachandran V, Ahmed Rayaz, Abraham Aby, George Biju, Srivastava Alok, Chandy Mammen, Mathews Vikram, Balasubramanian Poonkuzhali

Abstract excerpt

AIM: Cytidine deaminase (CDA) irreversibly deaminates cytarabine (Ara-C), a key component of acute myeloid leukemia (AML) induction and consolidation therapy. CDA overexpression results in Ara-C resistance, while decreased expression is associated with toxicity. We evaluated factors influencing variation in CDA mRNA expression in adult AML patients and normal controls, and how they contributed to Ara-C...

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PMID: 22304580
DOI: 10.2217/pgs.11.149

Genes

CDA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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