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Article

Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients.

Pharmacogenetics - 1 Nov 2004

Shi Jing-Yi, Shi Zhan-Zhong, Zhang Su-Jiang, Zhu Yong-Mei, Gu Bai-Wei, Li Guo, Bai Xue-Tao, Gao Xiao-Dong, Hu Jiong, Jin Wei, Huang Wei, Chen Zhu, Chen Sai-Juan

Abstract excerpt

Development of resistance to 1-beta-arabinofuranosylcytosine (AraC) is a major obstacle in the treatment of patients with acute myeloid leukaemia (AML). Deficiency of functional deoxycytidine kinase (dCK) plays an important role in AraC resistance in vitro. We screened 5378 bp sequences of the dCK gene, including all exons and the 5' flanking region, and identified two single nucleotide polymorphisms (SNPs) in...

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Identifiers

PMID: 15564883
DOI: 10.1097/00008571-200411000-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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