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Article

The role of local backrub motions in evolved and designed mutations.

PLoS computational biology - 1 Jan 2012

Keedy Daniel A, Georgiev Ivelin, Triplett Edward B, Donald Bruce R, Richardson David C, Richardson Jane S

Abstract excerpt

Amino acid substitutions in protein structures often require subtle backbone adjustments that are difficult to model in atomic detail. An improved ability to predict realistic backbone changes in response to engineered mutations would be of great utility for the blossoming field of rational prote...

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Identifiers

PMID: 22876172
DOI: 10.1371/journal.pcbi.1002629
PMCID: PMC3410847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22876172-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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