Article
Use of conserved key amino acid positions to morph protein folds.
Biopolymers - 15 Jul 2002
Reddy Boojala V B, Li Wilfred W, Bourne Philip E
Abstract excerpt
By using three-dimensional (3D) structure alignments and a previously published method to determine Conserved Key Amino Acid Positions (CKAAPs) we propose a theoretical method to design mutations that can be used to morph the protein folds. The original Paracelsus challenge, met by several groups, called for the engineering of a stable but different structure by modifying less than 50% of the amino acid residues....
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