Article
A fast method for predicting amino acid mutations that lead to unfolding.
Protein engineering - 1 Jul 2001
Wright J D, Lim C
Abstract excerpt
Amino acid mutation(s) that cause(s) partial or total unfolding of a protein can lead to disease states and failure to produce mutants. It is therefore very useful to be able to predict which mutations can retain the conformation of a wild-type protein and which mutations will lead to local or global unfolding of the protein. We have developed a fast and reasonably accurate method based on a backbone-dependent...
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