Article
The APOE ε4 allele is associated with increased frontally mediated neurobehavioral symptoms in amnestic MCI.
Alzheimer disease and associated disorders - 1 Jan 2000
Mikos Ania E, Piryatinsky Irene, Tremont Geoffrey, Malloy Paul F
Abstract excerpt
The apolipoprotein E ε4 allele is a risk factor for late-onset Alzheimer disease (AD), and the frontal lobes may be among the regions that manifest effects of ε4 even early in the disease. We predicted that among patients with amnestic mild cognitive impairment (aMCI) and AD, ε4 would be associated with increased neurobehavioral symptoms when assessed using a measure sensitive to frontal lobe integrity. We...
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