Article
Distribution and clinical impact of apolipoprotein E4 in subjective memory impairment and early mild cognitive impairment.
Scientific reports - 7 Aug 2020
Cho Hanna, Kim Young-Eun, Chae Wonjeong, Kim Ko Woon, Kim Jong-Won, Kim Hee Jin, Na Duk L, Ki Chang-Seok, Seo Sang Won
Abstract excerpt
The apolipoprotein E (APOE) e4 allele is the most common genetic variant associated with Alzheimer's disease (AD). We sought to investigate the distribution of APOE genotypes across the full clinical AD spectrum including AD, late-stage amnestic mild cognitive impairment (L-aMCI), early-stage aMC...
Topics
- Aged
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Case-Control Studies
- Cognitive Dysfunction
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Memory Disorders
- Middle Aged
- Neuropsychological Tests
- Prospective Studies