Article
Dendritic cell depletion in burn patients is regulated by MafB expression.
Journal of burn care & research : official publication of the American Burn Association - 1 Jan 2000
Williams Keneeshia N, Szilagyi Andrea, He Li-Ke, Conrad Peggie, Halerz Marcia, Gamelli Richard L, Shankar Ravi, Muthumalaiappan Kuzhali
Abstract excerpt
Studies have shown that monocytes are hyporesponsive and that dendritic cells (DCs) are depleted in burn patients. We have recently shown in a mouse model that burn injury alters the transcriptional regulation in bone marrow progenitors and inhibits myeloid-derived DC (mDC) production. In the present study, using human burn patient peripheral blood mononuclear cells, we have shown an overexpression of MafB with a...
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