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Article

In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha.

The Journal of clinical investigation - 1 Nov 2009

Connolly Michael K, Bedrosian Andrea S, Mallen-St Clair Jon, Mitchell Aaron P, Ibrahim Junaid, Stroud Andrea, Pachter H Leon, Bar-Sagi Dafna, Frey Alan B, Miller George

Abstract excerpt

Hepatic fibrosis occurs during most chronic liver diseases and is driven by inflammatory responses to injured tissue. Because DCs are central to modulating liver immunity, we postulated that altered DC function contributes to immunologic changes in hepatic fibrosis and affects the pathologic inflammatory milieu within the fibrotic liver. Using mouse models, we determined the contribution of DCs to altered hepatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19855130
DOI: 10.1172/JCI37581
PMCID: PMC2769179

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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