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Article

MafB is a critical regulator of complement component C1q

16 Nov 2017

Abstract excerpt

The transcription factor MafB is expressed by monocytes and macrophages. Efferocytosis (apoptotic cell uptake) by macrophages is important for inhibiting the development of autoimmune diseases, and is greatly reduced in Mafb-deficient macrophages. Here, we show the expression of the first protein in the classical complement pathway C1q is important for mediating efferocytosis and is reduced in Mafb-deficient...

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Share to Complement system in diseases
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Share to Renal Diseases and Glomerulopathies

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PMID: 29167450
DOI: 10.1038/s41467-017-01711-0

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