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Article

Tumor necrosis factor-alpha and CD95 ligation suppress erythropoiesis in Fanconi anemia C gene knockout mice.

Journal of cellular physiology - 1 Apr 1999

Otsuki T, Nagakura S, Wang J, Bloom M, Grompe M, Liu J M

Abstract excerpt

Fanconi anemia (FA) is a genetic syndrome predisposing to hematopoietic failure. Little is known about the pathophysiology of FA, except that tumor necrosis factor-alpha (TNF-alpha) is overexpressed in patients. FA group C (Fac) gene knockout mice have been developed in order to model the human disease, but the mice do not spontaneously exhibit aplasia. To investigate secondary influences on hematopoiesis in the...

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Source

Identifiers

PMID: 10082135
DOI: 10.1002/(SICI)1097-4652(199904)179:1<79::AID-JCP10>3.0.CO;2-O

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Tumor necrosis factor-alpha and CD95 ligation suppress erythropoiesis in Fanconi anemia C gene knockout mice.PMID 10082135Read ↗

Disease model: Fanconi anemia.Semantic proximity Read ↗

Germ cell defects and hematopoietic hypersensitivity to gamma- interferon in mice with a targeted disruption of the Fanconi anemia C geneSemantic proximity Read ↗

Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology: Underlying Mechanisms and Potential Therapeutic StrategiesSemantic proximity Read ↗

Germ cell defects and hematopoietic hypersensitivity to gamma- interferon in mice with a targeted disruption of the Fanconi anemia C geneSemantic proximity Read ↗

In vitro phenotypic correction of hematopoietic progenitors from Fanconi anemia group A knockout mice.Semantic proximity Read ↗

Mice with a targeted disruption of the Fanconi anemia homolog Fanca.Semantic proximity Read ↗

Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia.Semantic proximity Read ↗

Direct inhibition of TNF-α promoter activity by Fanconi anemia protein FANCD2.Semantic proximity Read ↗

Association of complementation group and mutation type with clinical outcome in fanconi anemia. European Fanconi Anemia Research Group.Semantic proximity Read ↗

Development and characterization of immortalized fibroblastoid cell lines from an FA(C) mouse model.Semantic proximity Read ↗

Aberrant activation of stress-response pathways leads to TNF-α oversecretion in Fanconi anemiaSemantic proximity Read ↗

Phenotypic correction of Fanconi anemia group C knockout mice.Semantic proximity Read ↗

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