MafB is an inducer of monocytic differentiation.

doi:10.1093/emboj/19.9.1987

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Article

MafB is an inducer of monocytic differentiation.

The EMBO journal - 2 May 2000

Kelly L M, Englmeier U, Lafon I, Sieweke M H, Graf T

Abstract excerpt

The bZip transcription factor MafB is expressed specifically in the myeloid lineage of the hematopoietic system and is up-regulated successively during myeloid differentiation from multipotent progenitors to macrophages. Here we report that this induction reflects an essential role of MafB in early myeloid and monocytic differentiation. We observed that the expression of MafB in transformed chicken hematopoietic...

Topics

Amino Acid Sequence
Animals
Avian Proteins
Biomarkers
Cell Differentiation
Cell Line, Transformed
Cell Size
Chick Embryo
Colony-Forming Units Assay
DNA-Binding Proteins
Genes, Dominant
Hematopoietic Stem Cells
Lipopolysaccharides
Macrophage Activation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macrophages

MafB Transcription Factor

Monocytes

Mutation

Source

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Identifiers

PMID: 10790365
DOI: 10.1093/emboj/19.9.1987
PMCID: PMC305687

Provenance

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