Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Injury-induced suppression of effector T cell immunity requires CD1d-positive APCs and CD1d-restricted NKT cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2006

Palmer Jessica L, Tulley Julia M, Kovacs Elizabeth J, Gamelli Richard L, Taniguchi Masaru, Faunce Douglas E

Abstract excerpt

Overwhelming infection remains the leading cause of death from serious burn injury despite recent advances in the care of burn patients and a better understanding of immune and inflammatory consequences of injury. In this study, we report a critical requirement for CD1d-restricted NKT cells and CD1d expression by APCs in the immune dysfunction that occurs early after burn injury. Using a well-established murine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoptive Transfer
Share to Antigen-Presenting Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antigens, CD1

Share to Antigens, CD1d

Share to Immune Tolerance

Share to Immunity, Cellular

Share to Interleukin-4

Source

Identifiers

PMID: 16785503
DOI: 10.4049/jimmunol.177.1.92

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Injury-induced suppression of effector T cell immunity requires CD1d-positive APCs and CD1d-restricted NKT cells.PMID 16785503Read ↗

CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity.Semantic proximity Read ↗

Nitric oxide contributes to the development of a post-injury Th2 T-cell phenotype and immune dysfunction.Semantic proximity Read ↗

Burn wound γδ T-cells support a Th2 and Th17 immune response.Semantic proximity Read ↗

Differential immunological phenotypes are exhibited after scald and flame burns.Semantic proximity Read ↗

CD4- CD8- TCR alpha/beta+ suppressor T cells demonstrated in mice 1 day after thermal injury.Semantic proximity Read ↗

Differential expression and tissue compartmentalization of the inflammatory response following thermal injury.Semantic proximity Read ↗

Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection.Semantic proximity Read ↗

Suppressor T-cell levels are unreliable indicators of the impaired immune response following thermal injury.Semantic proximity Read ↗

Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis.Semantic proximity Read ↗

Critical roles of conventional dendritic cells in promoting T cell-dependent hepatitis through regulating natural killer T cells.Semantic proximity Read ↗

T cells from burn-injured mice demonstrate a loss of sensitivity to glucocorticoids.Semantic proximity Read ↗

Resistance of CD1d-/- mice to ultraviolet-induced skin cancer is associated with increased apoptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.