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Article

Inhibition of neointimal hyperplasia in the rat carotid artery injury model by a HMGB1 inhibitor.

Atherosclerosis - 1 Oct 2012

Chen Jing, Zhang Jing, Xu Lin, Xu Changwu, Chen Sisi, Yang Jian, Jiang Hong

Abstract excerpt

OBJECTIVE: High mobility group box 1 protein (HMGB1) is expressed in atherosclerotic lesions. However, its role in vascular system is unknown. In this study, we explore whether the inhibition of HMGB1 attenuates neointimal formation in animal models. METHODS AND RESULTS: Experiments were performed with VSMCs from thoracic aorta of SD rats in vitro, and a rat carotid artery balloon injury model in vivo. HMGB1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22857898
DOI: 10.1016/j.atherosclerosis.2012.07.020

Genes

HMGB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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