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Article

High-mobility group box-1 and its role in angiogenesis

22 Jan 2014

Abstract excerpt

HMGB1 is an architectural chromatin-binding protein that can be released actively by activated cells or passively by dying cells and can serve as a DAMP molecule to drive the pathogenesis of inflammatory and angiogenic diseases. Through TLR4 and RAGE signaling pathways, HMGB1 could regulate vascular growth in vivo and in vitro through diverse mechanisms, including induction of proangiogenic cytokine release and...

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Identifiers

PMID: 24453275
DOI: 10.1189/jlb.0713412

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