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Article

High Mobility Group Box 1 Mediates TMAO-Induced Endothelial Dysfunction

22 Jul 2019

Abstract excerpt

The intestinal microbe-derived metabolite trimethylamine N-oxide (TMAO) is implicated in the pathogenesis of cardiovascular diseases (CVDs). The molecular mechanisms of how TMAO induces atherosclerosis and CVDs' progression are still unclear. In this regard, high-mobility group box protein 1 (HMGB1), an inflammatory mediator, has been reported to disrupt cell-cell junctions, resulting in vascular endothelial...

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PMID: 31336567
DOI: 10.3390/ijms20143570

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