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Article

Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Aug 2012

Han Harry J, Allen Carolyn C, Buchovecky Christie M, Yetman Michael J, Born Heather A, Marin Miguel A, Rodgers Shaefali P, Song Bryan J, Lu Hui-Chen, Justice Monica J, Probst Frank J, Jankowsky Joanna L

Abstract excerpt

The tet-off system has been widely used to create transgenic models of neurological disorders including Alzheimer's, Parkinson's, Huntington's, and prion disease. The utility of this system lies in the assumption that the tetracycline transactivator (TTA) acts as an inert control element and does not contribute to phenotypes under study. Here we report that neuronal expression of TTA can affect hippocampal...

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Identifiers

PMID: 22855807
DOI: 10.1523/JNEUROSCI.0893-12.2012
PMCID: PMC3431916

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F2

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