Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse.

Developmental biology - 1 Jan 2009

Morimoto Mitsuru, Kopan Raphael

Abstract excerpt

The doxycycline (DOX)-inducible gene expression systems allow tight temporal and spatial control of transgene expression, invaluable in studies of organ development and disease pathogenesis. Transgenic mice using the human Surfactant Protein C promoter to drive the expression of the reverse tetracycline transactivator (SP-C-rtTA) enabled functional analysis of essential gene function during lung development. Here...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Tetracycline
Share to Cell Survival
Share to Doxycycline

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Development

Share to Pulmonary Alveoli

Share to Pulmonary Surfactant-Associated Protein C

Share to Survival Analysis

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 19013447
DOI: 10.1016/j.ydbio.2008.10.013
PMCID: PMC2955437

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse.PMID 19013447Read ↗

Conditional Expression of Genes in the Respiratory Epithelium in Transgenic MiceSemantic proximity Read ↗

Airway-specific inducible transgene expression using aerosolized doxycycline.Semantic proximity Read ↗

Expression of a human surfactant protein C mutation associated with interstitial lung disease disrupts lung development in transgenic mice.Semantic proximity Read ↗

Targeted Type 2 Alveolar Cell Depletion. A Dynamic Functional Model for Lung Injury Repair.Semantic proximity Read ↗

Expression of the reverse tetracycline-transactivator gene causes emphysema-like changes in mice.Semantic proximity Read ↗

Unsuspected effects of a lung-specific Cre deleter mouse line.Semantic proximity Read ↗

Phenotypic Diversity Caused by Differential Expression of SFTPC-Cre-Transgenic Alleles.Semantic proximity Read ↗

Overexpression of surfactant protein-C mature peptide causes neonatal lethality in transgenic mice.Semantic proximity Read ↗

Normal surfactant pool sizes and inhibition-resistant surfactant from mice that overexpress surfactant protein A.Semantic proximity Read ↗

Conditional Expression of Fibroblast Growth Factor-7 in the Developing and Mature LungSemantic proximity Read ↗

A novel doxycycline‐inducible system for the transgenic analysis of mammary gland biologySemantic proximity Read ↗

Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.