Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex-related dimorphism in dentate gyrus atrophy and behavioral phenotypes in an inducible tTa:APPsi transgenic model of Alzheimer's disease.

Neurobiology of disease - 1 Dec 2016

Melnikova Tatiana, Park DaMin, Becker Lauren, Lee Deidre, Cho Eugenia, Sayyida Nuzhat, Tian Jing, Bandeen-Roche Karen, Borchelt David R, Savonenko Alena V

Abstract excerpt

Sex differences are a well-known phenomenon in Alzheimer's disease (AD), with women having a higher risk for AD than men. Many AD mouse models display a similar sex-dependent pattern, with females showing earlier cognitive deficits and more severe neuropathology than males. However, whether those differences are relevant to human disease is unclear. Here we show that in AD mouse models that overexpress amyloid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atrophy
Share to Conditioning, Psychological

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dentate Gyrus

Share to Locomotion

Share to Presenilin-1

Share to Recognition, Psychology

Share to Tetracycline

Source

Open in PubMed Open full text

Identifiers

PMID: 27569580
DOI: 10.1016/j.nbd.2016.08.009
PMCID: PMC6457346

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex-related dimorphism in dentate gyrus atrophy and behavioral phenotypes in an inducible tTa:APPsi transgenic model of Alzheimer's disease.PMID 27569580Read ↗

Sex‐specific accelerated decay in time/activity‐dependent plasticity and associative memory in an animal model of Alzheimer's diseaseSemantic proximity Read ↗

Sex differences in behaviour and molecular pathology in the 5XFAD modelSemantic proximity Read ↗

Sex Differences in Behavior and Molecular Pathology in the 5XFAD Model.Semantic proximity Read ↗

Females outperform males in spatial learning despite increased amyloid plaques and microgliosis in a TgF344-AD rat model of Alzheimer’s diseaseSemantic proximity Read ↗

Gender dependent APP processing in a transgenic mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic modelSemantic proximity Read ↗

Sexual Dimorphism in the 3xTg-AD Mouse Model and Its Impact on Pre-Clinical ResearchSemantic proximity Read ↗

Sex-Dependent Differences in Spontaneous Autoimmunity in Adult 3xTg-AD Mice.Semantic proximity Read ↗

Sexual dimorphism in behavior, neuropathology, and biomarkers in a tau P301S mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's diseaseSemantic proximity Read ↗

Gender-Dependent Transthyretin Modulation of Brain Amyloid-β Levels: Evidence from a Mouse Model of Alzheimer's DiseaseSemantic proximity Read ↗

Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.