Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect size of memory deficits in mice with adult-onset P301L tau expression.

Behavioural brain research - 1 Oct 2014

Hunsberger Holly C, Rudy Carolyn C, Weitzner Daniel S, Zhang Chong, Tosto David E, Knowlan Kevin, Xu Ying, Reed Miranda N

Abstract excerpt

Transgenic mice expressing mutations in tau have yielded essential discoveries for Alzheimer's disease. One of the most commonly used tau mouse models is the tet-off Tg(tauP301L)4510 model that expresses P301L human tau driven by the calcium-calmodulin kinase IIα (CaMKIIα) promoter system. Tau expression in this model is regulatable, allowing for suppression of mutant tau expression until adulthood and prevention...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Conditioning, Psychological
Share to CREB-Binding Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Maze Learning

Share to Memory Disorders

Share to Neuropsychological Tests

Share to tau Proteins

Share to Tauopathies

Source

Open in PubMed Open full text

Identifiers

PMID: 25004446
DOI: 10.1016/j.bbr.2014.06.057
PMCID: PMC4151262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect size of memory deficits in mice with adult-onset P301L tau expression.PMID 25004446Read ↗

Morris Water Maze Test: Optimization for Mouse Strain and Testing EnvironmentSemantic proximity Read ↗

Early Long-Term Memory Impairment and Changes in the Expression of Synaptic Plasticity-Associated Genes, in the McGill-R-Thy1-APP Rat Model of Alzheimer's-Like Brain AmyloidosisSemantic proximity Read ↗

Differential Effects of Human P301L Tau Expression in Young versus Aged Mice.Semantic proximity Read ↗

In vivo functional brain mapping in a conditional mouse model of human tauopathy (tauP301L) reveals reduced neural activity in memory formation structures.Semantic proximity Read ↗

Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia.Semantic proximity Read ↗

Performance of transgenic TgTau-P301L mice in a 5-choice serial reaction time task (5-CSRTT) as a model of Alzheimer's disease.Semantic proximity Read ↗

Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy.Semantic proximity Read ↗

Improved Long-Term Potentiation and Memory in Young Tau-P301L Transgenic Mice before Onset of Hyperphosphorylation and TauopathySemantic proximity Read ↗

Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats.Semantic proximity Read ↗

Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.Semantic proximity Read ↗

Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with agingSemantic proximity Read ↗

Learning and Memory in S100-β Transgenic Mice: An Analysis of Impaired and Preserved FunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.