Article
Effect size of memory deficits in mice with adult-onset P301L tau expression.
Behavioural brain research - 1 Oct 2014
Hunsberger Holly C, Rudy Carolyn C, Weitzner Daniel S, Zhang Chong, Tosto David E, Knowlan Kevin, Xu Ying, Reed Miranda N
Abstract excerpt
Transgenic mice expressing mutations in tau have yielded essential discoveries for Alzheimer's disease. One of the most commonly used tau mouse models is the tet-off Tg(tauP301L)4510 model that expresses P301L human tau driven by the calcium-calmodulin kinase IIα (CaMKIIα) promoter system. Tau ex...
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