Article
Transgenic inactivation of acetylcholinesterase impairs homeostasis in mouse hippocampal granule cells.
Hippocampus - 1 Jan 2008
Cohen J E, Zimmerman G, Melamed-Book N, Friedman A, Dori A, Soreq H
Abstract excerpt
In the adult murine hippocampus, dentate gyrus (DG), neurogenesis and neural cell death are thought to affect learning and memory in incompletely understood mechanism(s). Because cholinergic neurotransmission influences both of these functions, we hypothesized that cholinergic signaling, affected by acetylcholinesterase (AChE) activity, expression level, and alternative splicing, may provide a link between these...
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