Temporal and spatially controlled APP transgene expression using Cre-dependent alleles.

Abstract excerpt

Although a large number of mouse models have been made to study Alzheimer's disease, only a handful allow experimental control over the location or timing of the protein being used to drive pathology. Other fields have used the Cre and the tamoxifen-inducible CreER driver lines to achieve precise spatial and temporal control over gene deletion and transgene expression, yet these tools have not been widely used in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Amyloid beta-Protein Precursor