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Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment

22 Jun 2015

Abstract excerpt

The Morris water maze (MWM) is a commonly used task to assess hippocampal-dependent spatial learning and memory in transgenic mouse models of disease, including neurocognitive disorders such as Alzheimer's disease. However, the background strain of the mouse model used can have a substantial effect on the observed behavioral phenotype, with some strains exhibiting superior learning ability relative to others. To...

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PMID: 26132096
DOI: 10.3791/52706

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