Article
Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model.
Molecular neurodegeneration - 15 Jan 2014
Bailey Rachel M, Howard John, Knight Joshua, Sahara Naruhiko, Dickson Dennis W, Lewis Jada
Abstract excerpt
BACKGROUND: Cross-breeding of transgenic mice is commonly used to assess gene-gene interactions, particularly in the context of disease. Strain background changes can influence the phenotype of mouse models and can confound crossbreeding studies. We sought to determine if changing the strain background of a commonly used mouse model of tauopathy (rTg4510) would significantly impact the originally reported...
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