Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GATA-6 promotes cell survival by up-regulating BMP-2 expression during embryonic stem cell differentiation.

Molecular biology of the cell - 1 Sept 2012

Rong Li, Liu Jie, Qi Yanmei, Graham Alan M, Parmacek Michael S, Li Shaohua

Abstract excerpt

GATA-6 is a zinc-finger transcription factor essential for early embryogenesis. Ablation of GATA-6 in mice impairs endoderm differentiation and causes apoptosis of epiblast cells. The endoderm defects have been attributed to the loss of HNF4, disabled-2, and GATA-4. However, the mechanisms underlying epiblast apoptosis are unclear. In this study we used mouse embryonic stem cell-derived embryoid bodies (EBs) as a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein 2
Share to Embryoid Bodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Stem Cells

Share to Endoderm

Share to GATA6 Transcription Factor

Share to Immunoblotting

Share to Microscopy, Electron

Share to Smad Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22855527
DOI: 10.1091/mbc.E12-04-0313
PMCID: PMC3442421

Genes

SMAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GATA-6 promotes cell survival by up-regulating BMP-2 expression during embryonic stem cell differentiation.PMID 22855527Read ↗

GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo.Semantic proximity Read ↗

Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6.Semantic proximity Read ↗

Involvement of Ras in extraembryonic endoderm differentiation of embryonic stem cells.Semantic proximity Read ↗

Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.Semantic proximity Read ↗

GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.Semantic proximity Read ↗

GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas FormationSemantic proximity Read ↗

The transcription factor GATA6 is essential for early extraembryonic development.Semantic proximity Read ↗

Modulation of TGF-β signaling by endoglin in murine hemangioblast development and primitive hematopoiesis.Semantic proximity Read ↗

GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fateSemantic proximity Read ↗

A critical role for endoglin in the emergence of blood during embryonic developmentSemantic proximity Read ↗

A role for GATA5 in Xenopus endoderm specification.Semantic proximity Read ↗

The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.