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Article

A critical role for endoglin in the emergence of blood during embryonic development

26 Apr 2012

Abstract excerpt

Much remains unknown about the signals that induce early mesoderm to initiate hematopoietic differentiation. Here, we show that endoglin (Eng), a receptor for the TGFβ superfamily, identifies all cells with hematopoietic fate in the early embryo. These arise in an Eng(+)Flk1(+) mesodermal precursor population at embryonic day 7.5 (E7.5), a cell fraction also endowed with endothelial potential. In Eng-knockout...

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PMID: 22535663
DOI: 10.1182/blood-2011-11-391896

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