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Article

Modulation of TGF-β signaling by endoglin in murine hemangioblast development and primitive hematopoiesis.

Blood - 7 Jul 2011

Zhang Liying, Magli Alessandro, Catanese Jacquelyn, Xu Zhaohui, Kyba Michael, Perlingeiro Rita C R

Abstract excerpt

Endoglin (Eng), an accessory receptor for the transforming growth factor β (TGF-β) superfamily, is required for proper hemangioblast and primitive hematopoietic development. However the mechanism by which endoglin functions at this early developmental stage is currently unknown. Transcriptional analyses of differentiating eng(-/-) and eng(+/+) ES cells revealed that lack of endoglin leads to profound reductions...

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Source

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Identifiers

PMID: 21602526
DOI: 10.1182/blood-2010-12-325019
PMCID: PMC3139390

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Modulation of TGF-β signaling by endoglin in murine hemangioblast development and primitive hematopoiesis.PMID 21602526Read ↗

A critical role for endoglin in the emergence of blood during embryonic developmentSemantic proximity Read ↗

Endoglin regulates the integrity of the bone marrow vasculatureSemantic proximity Read ↗

Endoglin Regulates the Activation and Quiescence of Endothelium by Participating in Canonical and Non-Canonical TGF-β Signaling PathwaysSemantic proximity Read ↗

Endoglin Requirement for BMP9 Signaling in Endothelial Cells Reveals New Mechanism of Action for Selective Anti-Endoglin AntibodiesSemantic proximity Read ↗

Endoglin is required in Pax3-derived cells for embryonic blood vessel formation.Semantic proximity Read ↗

ENDOGLIN Is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-Induced AngiogenesisSemantic proximity Read ↗

Smad1 expands the hemangioblast population within a limited developmental windowSemantic proximity Read ↗

Endothelial cell biology of Endoglin in hereditary hemorrhagic telangiectasia.Semantic proximity Read ↗

Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor.Semantic proximity Read ↗

Novel biochemical pathways of endoglin in vascular cell physiologySemantic proximity Read ↗

Interaction and functional interplay between endoglin and ALK‐1, two components of the endothelial transforming growth factor‐β receptor complexSemantic proximity Read ↗

Defective Angiogenesis in Mice Lacking EndoglinSemantic proximity Read ↗

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