Article
GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo.
Genes & development - 15 Nov 1998
Morrisey E E, Tang Z, Sigrist K, Lu M M, Jiang F, Ip H S, Parmacek M S
Abstract excerpt
GATA6 belongs to a family of zinc finger transcription factors that play important roles in transducing nuclear events that regulate cellular differentiation and embryonic morphogenesis in vertebrate species. To examine the function of GATA6 during embryonic development, gene targeting was used t...
Topics
- 3T3 Cells
- Animals
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Cell Differentiation
- DNA-Binding Proteins
- Embryo, Mammalian
- Embryonic and Fetal Development
- Endoderm
- GATA6 Transcription Factor
- Gene Expression Regulation, Developmental
- Gene Targeting
- Genotype
- Hepatocyte Nuclear Factor 4
- Histocytochemistry