Article
The transcription factor GATA6 is essential for early extraembryonic development.
Development (Cambridge, England) - 1 Feb 1999
Koutsourakis M, Langeveld A, Patient R, Beddington R, Grosveld F
Abstract excerpt
The gene coding for the murine transcription factor GATA6 was inactivated by insertion of a beta-galactosidase marker gene. The analysis of heterozygote GATA6/lacZ mice shows two inductions of GATA6 expression early in development. It is first expressed at the blastocyst stage in part of the inne...
Topics
- Animals
- Blastocyst
- Cell Differentiation
- Chimera
- DNA-Binding Proteins
- Embryonic and Fetal Development
- GATA6 Transcription Factor
- Gene Expression Regulation, Developmental
- Gene Targeting
- Genes, Lethal
- Genotype
- Histocytochemistry
- In Situ Hybridization
- In Situ Hybridization, Fluorescence
- Lac Operon
- Mice
- Recombination, Genetic
- Stem Cells